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Materials and Methods

Estrogen deprivation causes estradiol hypersensitivity in human breast cancer cells. The first report that the acquired resistance of breast cancer cells in vitro to oestrogen deprivation is due to their acquisition of hypersensitivity to residual oestrogens. Effect of estrogens and antiestrogens on growth of human breast cancer cells in athymic nude mice. Johnston, S. Idoxifene antagonizes estradiol-dependent MCF-7 breast cancer xenograft growth through sustained induction of apoptosis.

Detre, S. Time-related effects of oestrogen withdrawal on proliferation and cell death-related events in MCF-7 xenografts.

Cancer 81 , — Brodie, A. Predictions from a preclinical model: studies of aromatase inhibitors and antiestrogens.

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Simpson, E. Aromatase and its inhibitors: significance for breast cancer therapy. Miller, W. Aromatase and its inhibitors: new biology and clinical perspectives. Cancer 6 , — Endogenous sex hormones and breast cancer in postmenopausal women: reanalysis of nine prospective studies. Natl Cancer Inst. Clear demonstration that there is a direct association between plasma oestradiol and some other steroids with breast cancer risk in postmenopausal women. Means, G. Structural analysis of the gene encoding human aromatase cytochrome P, the enzyme responsible for estrogen biosynthesis.

Kristensen, V. A rare CYP19 aromatase variant may increase the risk of breast cancer. Pharmacogenetics 8 , 43—48 Haiman, C. No association between a single nucleotide polymorphism in CYP19 and breast cancer risk. Cancer Epidemiol. Biomarkers Prev. Healey, C. Polymorphisms in the human aromatase cytochrome P gene CYP19 and breast cancer risk.

Aromatase Inhibitors for Lowering Breast Cancer Risk

Carcinogenesis 21 , — Masi, L. Polymorphism of the aromatase gene in postmenopausal Italian women: distribution and correlation with bone mass and fracture risk. Dowsett, M.

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Association of Cyp19 aromatase and SHBG gene polymorphisms with plasma hormone levels in postmenopausal women: implications for breast cancer. Breast Cancer Res.

Aromatase inhibitors for breast cancer: lessons from the laboratory | Nature Reviews Cancer

Pasqualini, J. Concentrations of estrone, estradiol, and estrone sulfate and evaluation of sulfatase and aromatase activities in pre- and postmenopausal breast cancer patients. The importance of local synthesis of estrogen within the breast. Steroids 50 , — Seminal data on the importance of oestrogen production in normal and malignant breast tissues. Bulun, S. Distribution of aromatase P transcripts and adipose fibroblasts in the human breast. Harada, N. Tissue-specific expression of the human aromatase cytochrome P gene by alternative use of multiple exons 1 and promoters, and switching of tissue-specific exons 1 in carcinogenesis.

Natl Acad. USA 90 , — Schrey, M.

Molecular response to aromatase inhibitor treatment in primary breast cancer

Prostaglandin E2 production and metabolism in human breast cancer cells and breast fibroblasts. Regulation by inflammatory mediators. Cancer 72 , — Coombes, R. Cancer 28A , — Lonning, P. Pharmacology and clinical experience with exemestane. Expert Opin. Drugs 9 , — Kao, Y. Binding characteristics of seven inhibitors of human aromatase: a site-directed mutagenesis study.

Theoretical considerations for the ideal aromatase inhibitor. Geisler, J. Influence of letrozole and anastrozole on total body aromatization and plasma estrogen levels in postmenopausal breast cancer patients evaluated in a randomized, cross-over study. Demonstration of the near-complete aromatase inhibition and oestrogen suppression that is achieved by third-generation non-steroidal aromatase inhibitors. Harper-Wynne, C. Comparison of the systemic and intratumoral effects of tamoxifen and the aromatase inhibitor vorozole in postmenopausal patients with primary breast cancer.

Differences in the molecular effects of aromatase inhibitors and tamoxifen are clearly shown in this paper — the first randomized neoadjuvant endocrine study in breast cancer. Sinha, S. Effect of CGS on ovarian aromatase and gonadotropin levels in the rat.

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Aromatization inhibition alone or in combination with GnRH agonists for the treatment of premenopausal breast cancer patients. Steroid Biochem. Buzdar, A. Anastrozole, a potent and selective aromatase inhibitor, versus megestrol acetate in postmenopualsa women with advanced breast cancer: results of overview analysis of two phase III trials.

Dombernowsky, P.

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  4. Letrozole, a new oral aromatase inhibitor for advanced breast cancer: double-blind randomised trial showing a dose-effect and improved efficacy and tolerability compared with megestrol acetate. Kaufmann, M. Exemestane is superior to megesterol acetate after tamoxifen failure in postmenopausal women with advanced breast cancer: results of a phase III randomised double-blind trial.


    Tamoxifen versus aminoglutethimide versus combined tamoxifen and aminoglutethimide in the treatment of advanced breast carcinoma. Falkson, C. A randomised study of GCS A fadrozole versus tamoxifen in previoulsy untreated postmenopausal patients with metastatic breast cancer. Thurlimann, B. Bonneterre, J. Anastrozole is superior to tamoxifen as first-line therapy in hormone-receptor positive advanced breast carcinoma.

    Cancer 92 , — Mouridsen, H.